SPR Finds Small-Molecule Binders For CHI3L1, A Hard Cancer Target Cancer cells often rely on proteins that don't behave like typical enzymes to survive and spread. One such protein is CHI3L1 (also called YKL-40) , which cancer cells secrete to communicate with ... brain cancer cancer CHI3L1 drug discovery glioblastoma small molecules SPR STAT3 surface plasmon resonance YKL-40