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The Art of LLM System Design: Navigating Choices for Maximum Impact

Why LLM Selection Is More Strategic Than Ever

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In today’s fast-changing AI landscape, picking the right large language model (LLM) is both a challenge and a strategic imperative for business processes. With models continually emerging, each offering specialized strengths such as advanced reasoning, efficient code generation, or reduced costs; the decision process demands careful consideration. 

While the cost of LLMs is dropping, access to the latest capabilities may still be expensive, especially for organizations with large-scale or specialized requirements. Early choices about model size, inference strategy, and deployment method have a direct and lasting impact on feasibility and ongoing costs.

How LLM Performance Has Evolved

LLM performance advancements once came from scaling up compute, model size, and data. Today, improvements hinge on high-quality training data, innovative architectures, and advanced post-training techniques like instruction tuning and reinforcement learning from feedback. 

Modern models often “think harder” during inference, leveraging more compute for stronger reasoning, offering new ways to scale both capabilities and costs. As a result, model selection is no longer just about benchmarks, but about aligning features, latency, and expenses with your real-world needs.

Understanding Inference Cost Drivers

  • Model size scaling: Larger models typically deliver higher accuracy, but at a greater cost per token.

  • Series scaling (“thinking tokens”): Deeper reasoning means more compute per answer, which is especially relevant in agentic systems.

  • Parallel scaling: Running models in parallel can improve reliability but significantly increases costs.

  • Input context scaling: Feeding more or larger documents to a model raises both token costs and latency.

These levers can create enormous cost differences for similar tasks—sometimes by orders of magnitude. The goal is to balance capability, speed, and expense to fit your unique application.

What to Consider When Choosing an LLM

Effective model selection starts by understanding your use case and the AI capabilities required. While benchmarks like LiveBench and MMLU-Pro offer guidance, real-world performance often diverges from leaderboard results. Custom evaluations tailored to your business needs are essential. Key attributes to examine include:

  • Multimodality: Can the model handle text, images, or audio?
  • Context window: How much information can it process in one go?
  • Latency: Is response speed sufficient for interactive use?
  • Reasoning capability: Does it support complex, multistep problem-solving?
  • Privacy and security: Are data regulations and sensitivities addressed?
  • Trustworthiness: Is the model reliable, and does the vendor have a solid reputation?
  • Knowledge cutoff: Is the model’s training data recent enough for your domain?

The right balance of attributes, cost, and reliability ensures a justified investment—especially if greater efficiency or accuracy saves more than it costs to implement.

Open-Weight vs. Closed-API Models: Making the Right Trade-offs

High-performing open-weight models like Llama, Mistral, DeepSeek, and Qwen have shifted the AI ecosystem. Open models give you flexibility, security, and fine-tuning options for specialized needs. Closed-API models from major providers offer state-of-the-art performance with simplicity and scale. Increasingly, hybrid approaches—such as third-party hosting of open models—blend both worlds. Your decision should reflect regulatory, operational, and financial considerations.

Six Steps to Effective LLM System Design

1. Open or Closed?
  • Choose closed-API models for the latest features and ease of use.
  • Pick open-weight models when you need data security, customization, or fine-tuning.
2. Consider Reasoning Needs
  • Use advanced models for complex, multistep tasks.
  • For simpler applications, avoid overpaying for unnecessary power.
  • “Mini” models can offer cost-effective alternatives.
3. Match Model Attributes to Application Goals
  • Prioritize accuracy, speed, or long context as your use case demands.
  • Opt for multimodal models if your app involves images or audio.
4. Escalate Complexity Thoughtfully
  • Begin with prompt engineering.
  • Add retrieval-augmented generation (RAG) when needed.
  • Iterate and evaluate using custom metrics.
5. Fine-Tuning and Distillation
  • Fine-tune open-weight models for specialized tasks.
  • Use distillation and reinforcement learning to boost efficiency.
6. Orchestrated Workflows vs. Autonomous Agents
  • Use orchestrated, linear workflows for predictable tasks.
  • Hybrid pipelines often deliver the best performance.
  • Deploy autonomous agents for open-ended problems, but enforce guardrails to control costs.

Success Lies in Thoughtful Engineering

The LLM landscape is both opportunistic and complex. Achieving success means taking a systematic approach—from strategic data decisions to tactical choices about features and costs. The real skill lies in architecting tailored solutions, not just picking from a list. Ongoing custom evaluation keeps your system aligned with real-world needs, ensuring lasting value from your LLM investment.

Source: O’Reilly Radar, “LLM System Design and Model Selection” by Louis-François Bouchard and Louie Peters

The Art of LLM System Design: Navigating Choices for Maximum Impact
Joshua Berkowitz December 21, 2025
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