Building the next generation of intelligent agents, robots, and biomedical breakthroughs without barriers is getting closer thanks to AI advancements at NVIDIA. They are releasing a comprehensive suite of open models, datasets, and developer tools to help research and commercial applications. By embracing open source, NVIDIA is democratizing access to advanced AI and fostering a culture of rapid, collaborative innovation across the globe.
Expanding the Open AI Ecosystem
NVIDIA’s latest initiative unveils four powerful families of open models:
- NVIDIA Nemotron for digital AI and advanced reasoning
- Cosmos for physical AI and world simulation
- Isaac GR00T for robotics and embodied intelligence
- Clara for biomedical research and healthcare
Now accessible on platforms like Hugging Face and build.nvidia.com, these resources offer developers a robust foundation for creating specialized AI solutions. With over 650 open models and 250 datasets, NVIDIA is cementing its leadership in the open-source AI movement.
Nemotron: Next-Level Reasoning for Specialized Agents
The Nemotron family introduces models designed for efficiency and explainability:
- Nemotron Nano 3 delivers fast, hybrid reasoning for IT and customer support use cases.
- Nemotron Nano 2 VL powers document intelligence and visual analysis.
- Nemotron Parse extracts actionable insights from complex documents.
- Nemotron Safety Guard moderates multilingual content across 23 safety categories.
- Nemotron RAG enables unified retrieval and generation across text, images, audio, and video.
Developers can leverage open datasets for multimodal training, privacy-preserving synthetic data, and multicultural personas. Enhanced NeMo tools now allow for synthetic data creation and reinforcement learning, making it easier to customize and deploy specialized models.
Industry Impact: Agentic AI in Real-World Applications
Enterprise leaders are already integrating NVIDIA’s open models into their platforms. ServiceNow uses Nemotron for Apriel 2.0 in regulated industries, while Palantir, Cadence, CrowdStrike, PayPal, Synopsys, and Zoom harness these models to enhance productivity, security, and efficiency. These real-world deployments highlight the transformative potential of open-weight, explainable AI where trust and compliance are critical.
Cosmos & Isaac GR00T: Advancing Physical AI and Robotics
The Cosmos and Isaac GR00T models dramatically accelerate the development of AI systems with humanlike perception and reasoning:
- Cosmos Predict 2.5 simulates real-world scenarios, generating detailed 30-second videos from a single frame.
- Cosmos Transfer 2.5 creates high-quality synthetic data at a fraction of the usual size.
- Cosmos Reason provides advanced multimodal understanding as a deployable microservice.
- Cosmos Dataset Search streamlines the retrieval of training scenarios for faster development.
- Isaac GR00T N1.6 boosts control and generalization for humanoid robots.
With the release of the largest open-source physical AI dataset and adoption by leaders like Agility Robotics and Amazon Robotics, these tools are setting new standards for generating synthetic data, teaching robots, and scaling physical AI systems.
Clara: Transforming Healthcare and Life Sciences
The Clara suite is revolutionizing research and medical imaging:
- Clara CodonFM deciphers RNA rules for more effective therapy and medicine design.
- Clara La-Proteina facilitates the creation of complex 3D protein structures for drug and enzyme development.
- Clara Reason brings explainable reasoning to medical imaging and radiology workflows.
Collaboration with initiatives like the Chan Zuckerberg Initiative’s virtual cells platform further accelerates progress in open-source biomedical AI research.
Secure and Accessible Deployment
NVIDIA’s open models are easily accessible through Hugging Face, build.nvidia.com/, and major cloud providers. Secure, scalable deployment as microservices via NVIDIA NIM ensures privacy, control, and seamless integration with existing infrastructure.
Open Collaboration Fuels the AI Revolution
By making advanced AI models and datasets widely available, NVIDIA is empowering developers and organizations to innovate faster and solve real-world challenges. The company’s commitment to openness, transparency, and collaboration is redefining what’s possible in artificial intelligence.
Source: NVIDIA Blog

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NVIDIA’s Open Models: Accelerating AI Innovation Across Industries