Scientific discovery is entering a new era at Lawrence Berkeley National Laboratory. By integrating artificial intelligence (AI) and automation into every facet of research, the Lab is not only accelerating discoveries but also redefining what is possible for scientists worldwide.
Revolutionizing Materials Discovery
Traditionally, materials science has relied on slow, manual experimentation. Now, Berkeley Lab’s facilities like A-Lab utilize AI to propose and refine new compounds, while robotics automate the preparation and testing process. This combination allows for rapid validation of materials crucial to next-generation technologies.
- A-Lab: Automated workflows powered by machine learning and robotics test thousands of compounds swiftly, reducing the timeline from months to days.
- Autobot at the Molecular Foundry: This system supports the search for materials in energy storage and quantum computing, making experiments more adaptive and efficient.
Smarter Instruments Through AI
Precision and adaptability are essential for advanced scientific tools. Berkeley Lab employs AI to optimize and stabilize complex instruments, maximizing efficiency and research impact.
- Berkeley Lab Laser Accelerator (BELLA): Machine learning models continuously calibrate laser and electron beams, minimizing manual intervention and expanding experimental opportunities.
- ALS-U: Deep-learning controls will soon optimize performance at the Advanced Light Source Upgrade, enhancing capabilities for researchers nationwide.
Real-Time Insights from Massive Data
Modern experiments create enormous data streams. Berkeley Lab’s integration of AI and automation enables instant data analysis, empowering scientists to adjust experiments in real time and draw conclusions at unprecedented speed.
- Supercomputing Integration: Instruments deliver data directly to supercomputers like Perlmutter at NERSC for near-instant analysis.
- Distiller Platform: This tool enables real-time data analysis at the National Center for Electron Microscopy, reducing costs and accelerating discovery.
- Fusion Research: Machine learning predicts particle dynamics within fusion plasmas, guiding smarter reactor controls for future energy solutions.
- ESnet’s AI-Enhanced Networks: AI anticipates and resolves network bottlenecks, enabling seamless, data-heavy collaboration across research institutions.
AI as a Scientific Collaborator
Artificial intelligence has graduated from being just a tool to becoming a trusted co-creator in scientific innovation. Berkeley Lab teams partner with AI systems to validate and critique external discoveries, ensuring new ideas move swiftly from prediction to application. For example, when AI-designed enzymes emerged in medical research, Berkeley Lab scientists used advanced imaging at the ALS to confirm their structure and function—bridging the gap between digital innovation and real-world impact.
- Protein Design Validation: Examining AI-generated enzymes helps accelerate advances in fields like medicine and sustainable energy.
The Future: AI at Every Stage of Science
With AI and automation embedded throughout research, Berkeley Lab’s scientists are freed from repetitive tasks and empowered to innovate in real time. This approach not only accelerates discovery but also ensures that America remains at the forefront of scientific achievement. As these technologies become standard, the Lab is building the infrastructure needed to tackle the world’s most complex scientific and technological problems.
Conclusion
By weaving AI and automation into the fabric of research, Berkeley Lab is transforming the pace and scope of scientific discovery. Their pioneering approach sets the stage for a future where rapid, collaborative innovation benefits both science and society.

AI and Automation Are Accelerating Scientific Discovery at Berkeley Lab